About the Journal

iCell is a newly established, peer-reviewed journal dedicated to the dissemination of cutting-edge research in cellular biology. The journal focuses on innovative studies that advance our understanding of cellular processes, mechanisms, and applications in medicine and biotechnology.

Current Issue

Vol. 3 No. 1 (2026): Volume 3, Issue 1

Circular RNAs play important yet incompletely understood roles in regulating autophagy during hepatocellular carcinoma (HCC) progression. This study identifies circR-4600 (hsa_circ_0005927) as a downregulated circRNA in HCC tissues, where its low expression correlates with poor patient prognosis. Mechanistically, circR-4600 interacts with the RNA-binding protein DVL3, attenuates its inhibition on DAB2, and thereby suppresses ATG5-mediated autophagy, ultimately inhibiting HCC cell proliferation, invasion, and metastasis. These findings reveal a novel circRNA-protein axis regulating autophagy in HCC and highlight circR-4600 as a potential therapeutic target. Image credit: Cover article.

Published: 2026-04-24

Articles

  • BioPE-RV: A New Paradigm for Biomedical Relation Extraction Integrating Prompt Engineering and Explicit Rule Verification

    Yani Yang, Xingrao Li, Jianping Zhou, Tingwei Lyu, Yuxiao He, Yongjian Zhou, Xuanyu Pan, Yanling Hu (Author)
    1-11

  • The widespread regulatory role of the phosphorylation of RNA-binding proteins (RBPs) in RNA abnormalities

    ZiYi Liu, Jinwan Li, Ping Cui, An Sanqi, Jing Leng (Author)
    12-22

  • Family-based integrative genomics identifies neural–metabolic–skeletal pathways underlying scoliosis susceptibility

    Xuanchen Li, Zhenrui Lin, Xiaosheng Chen, Zhixiang Zhu, Rui Zhang, Weijun Wang, Wenyu Zhou, Lei Yang, Yi He, Lihe Jiang, Guodong Huang, Qian Liang (Author)
    23-32

  • Bioinformatics analysis and the clinical significance of TP73 in regulating the immune microenvironment and chemosensitivity of endometrial cancer

    Jia Lu, Tongyan Yang, Junjie Ye, Yunyi Chen, Dejun Nong, Jiangtao Fan (Author)
    33-46
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