Vol. 2 No. 4 (2025): Volume 2, Issue 4

View Vol. 2 No. 4 (2025): Volume 2, Issue 4

Circular RNAs play important yet incompletely understood roles in regulating autophagy during hepatocellular carcinoma (HCC) progression. This study identifies circR-4600 (hsa_circ_0005927) as a downregulated circRNA in HCC tissues, where its low expression correlates with poor patient prognosis. Mechanistically, circR-4600 interacts with the RNA-binding protein DVL3, attenuates its inhibition on DAB2, and thereby suppresses ATG5-mediated autophagy, ultimately inhibiting HCC cell proliferation, invasion, and metastasis. These findings reveal a novel circRNA-protein axis regulating autophagy in HCC and highlight circR-4600 as a potential therapeutic target. Image credit: Cover article.

Published: 2025-12-31

Articles

  • Detection and genetic characterization of Densvirus from Oriental Pied hornbill in Guangxi, China

    NADA HASSAN, Lanxiang Li, Mariusz Giergiel, Teng- Cheng Que (Author)

  • Circular RNA circR-4600 inhibits hepatocellular carcinoma progression by suppressing autophagy through DVL3 and DAB2 interaction

    Gang Wang, Shaoliang Zhu, Zhizhong Chen, Yulin Yuan, Qiuxia Wei, Hongwei Wang, Tao Yang, Ling Cai, Xiaosu Zou, Wenqian Nong, Qicong Chen, Lequn Li, Xiaofeng Dong, Feixiang Wu, Honglin Luo (Author)

  • Enhancing Undergraduate Academic Writing in the Context of Medical Research: A Comprehensive Training Framework

    Yong Cao, Ying Wen, Xuan Li, Hongbin Huang, Liyi Zou, Yong Liu, Zunna Huang (Author)

  • A bibliometric analysis of RNA methylation in prostate cancer and its complications from 2003 to 2024

    Huifeng Wang, Xiangyuan Wei, Junjie Ye, Bo Xie, Junling Shan, Xiangfa Deng, Die Zhang, Lu Xu, Zengjing Liu, Nada M.A. Hassan, Chao Liu, Yu`ang Mao (Author)

Reviews

  • Artificial Intelligence in Immunoinformatics: From Multi-Omics to Precision Immunology

    ZiYi Liu, An Sanqi, Wenxing Li (Author)