Vol. 3 No. 1 (2026): Volume 3, Issue 1

View Vol. 3 No. 1 (2026): Volume 3, Issue 1

Pan-cancer phosphoproteomics identifies pervasive hyperphosphorylation of RNA-binding proteins as a core driver of tumor RNA dysfunction. This study pinpoints NCL T76 phosphorylation as a conserved prognostic risk signal across multiple cancers, controlled by CDK2 kinase. The small-molecule inhibitor TG-02 suppresses NCL T76 phosphorylation, revealing the CDK2–NCL T76 axis as a promising therapeutic target for solid tumors. Image credit: Cover article.

Published: 2026-04-24

Articles

  • BioPE-RV: A New Paradigm for Biomedical Relation Extraction Integrating Prompt Engineering and Explicit Rule Verification

    Yani Yang, Xingrao Li, Jianping Zhou, Tingwei Lyu, Yuxiao He, Yongjian Zhou, Xuanyu Pan, Yanling Hu (Author)
    1-11

  • The widespread regulatory role of the phosphorylation of RNA-binding proteins (RBPs) in RNA abnormalities

    ZiYi Liu, Jinwan Li, Ping Cui, An Sanqi, Jing Leng (Author)
    12-22

  • Family-based integrative genomics identifies neural–metabolic–skeletal pathways underlying scoliosis susceptibility

    Xuanchen Li, Zhenrui Lin, Xiaosheng Chen, Zhixiang Zhu, Rui Zhang, Weijun Wang, Wenyu Zhou, Lei Yang, Yi He, Lihe Jiang, Guodong Huang, Qian Liang (Author)
    23-32

  • Bioinformatics analysis and the clinical significance of TP73 in regulating the immune microenvironment and chemosensitivity of endometrial cancer

    Jia Lu, Tongyan Yang, Junjie Ye, Yunyi Chen, Dejun Nong, Jiangtao Fan (Author)
    33-46

  • Integrative Machine Learning-Based Framework For the Identification of Biomarkers of Immunogenic Cell Death and Comprehensive Pharmacological Screening Strategy in Sepsis

    Qiuli Chen, Yongbing Yu, Fanyan Ou, Houyu Gan, Lixiong Zeng, Junzhi Yang, Binbin Li, Qian Guo, Kanglai Wei, Jihua Feng, Jianfeng Zhang, Jie Yang (Author)
    46-64