Exosomal miRNAs in Inflammatory Diseases

Abstract

Exosomal miRNAs are a type of non-coding RNA molecules present in exosomes. MiRNAs are involved in the regulation of a variety of physiological and pathological processes by transmitting information between cells through the exosome, a carrier of intercellular communication. During inflammatory responses, exosomal miRNAs can be involved in regulating the activation of inflammatory cells and the release of inflammatory mediators, thus affecting the development of inflammatory diseases. Therefore, exosomal miRNAs may be promising biomarkers for monitoring disease progression based on their functions and changes. In addition, since exosome prevents miRNAs from being degraded by RNase, drug development targeting the release of exosomal miRNA contents lays the foundation for innovative targeted therapies in the future. This review focuses on exosomal miRNAs with the aim of combing and mastering its latest developments in the current research of inflammatory diseases.