RNA-Binding Proteins: Biological Mechanisms and Their Impact on Osteoporosis Development

Abstract

Osteoporosis is a common bone disease characterized by reduced bone mass and increased fracture risk, largely driven by imbalances in osteoblast and osteoclast activity. Recent studies highlight the critical role of RNA-binding proteins (RBPs) in the regulation of bone metabolism, specifically in osteoblast and osteoclast function. These proteins have also been implicated in other bone diseases, suggesting a broader influence on skeletal health. This review explores the molecular mechanisms through which RBPs impact bone cells, discusses their potential as therapeutic targets in osteoporosis, and outlines future research directions and challenges in harnessing RBPs for clinical applications.